Research papers on stem cells

Stem cell research articles pdf

They comprise the complete continuum of research from preliminary explorative studies through preclinical and clinical trails. Consequently, these cells became known as multipotent cells. Downs Blvd. A seminal paper from a group led by Catherine Verfaillie see Jiang et al. Unfortunately, little success has been made in replicating these results. Stephen K. This article offers a general overview of stem cells, their potential for extending life and improving its overall quality, and some thoughts on the role of health educators with regard to professional and lay audiences. Current treatments include nuclear radiation exposure and transplantation for the treatment of genetic diseases or cell cancers of the blood and the blood-forming system. Assuming that no contamination of the cell line occurs as a result of mutations or infections, and no differentiating triggers occur, the cell lines could potentially grow ad infinitum. It is believed that they are able to differentiate into a variety of cell types, but it is not known whether they are as pluripotent as other types of stem cells. Studies on stroke models using umbilical cord blood—derived stem cells do not support the idea of replacement, but do show an improvement in the size of the stroke lesion and behavioral markers. Further research is needed to explore the validity of this hypothesis, though the findings are certainly intriguing and potentially useful. However, ambiguity still exists on the identity and function of mesenchymal cells from differential tissue sources. These specialized cells are discussed below. The development of rigorous preclinical models is necessary to predict human cardiotoxicity and elucidate the underlying mechanisms of cardiotoxicity.

As of yet, however, it is unclear exactly what impact this action has on the growing organism and whether such studies can be confirmed. At this time, embryonic stem cells continue to proliferate and are said to be pluripotent or plastic, meaning that they can differentiate into almost any type of cell that makes up the body.

Stem cell articles for students

This research encompasses treatment of various disorders including organ regeneration, cardiovascular improvements, diabetes, and neurodegenerative conditions. For instance, ReNeuron, Inc. There is also the potential to model a disease more directly by removing the affected cells from a patient and growing them in culture so that they can be characterized and compared with healthy cells. It is important to remember, however, that embryonic stem cell research has never been illegal in the United States; it just cannot be funded from federal sources other than those lines that were approved in August See other articles in PMC that cite the published article. The focus of this controversy is on when life begins—which some consider to be at conception—and whether any individual has the right to terminate a life. Phillip J. Press Releases. Elsewhere, a study using embryonic stem cells has shown considerable improvement in mice specially bred to exhibit symptoms of Sandhoff disease, a childhood disorder. Marty and Robert J. It is believed that they are able to differentiate into a variety of cell types, but it is not known whether they are as pluripotent as other types of stem cells. If this speculation is true, then one would expect the body to have large numbers of these cells, which it does not. Interestingly, studies using embryonic carcinoma cells—which are malignant, similar to stem cells, and generally derived from germinal cells—have provided some neurodegenerative improvement in animal models.

One caveat to consider in stem cell treatment of disease is that the replacement of dying cells by new ones is only a temporary solution because whatever resulted in the death of the cells initially—unless purely intrinsic to the dying cells themselves or only a onetime event—will eventually prove lethal to the new cells, too.

There is also concern over the retroviruses used to insert the genes, which can have potentially carcinogenic and other detrimental effects due to their ability to randomly insert the gene of interest into the genome.

stem cell therapy research

Similarly, preliminary testing of the recently discovered stem cells in amniotic fluid for treating heart disease has demonstrated some encouraging results that require further study and verification. It is believed that they are able to differentiate into a variety of cell types, but it is not known whether they are as pluripotent as other types of stem cells.

Preliminary findings from other studies involving fetal neural stem cells in culture and in animals have shown rescue of retinal cells after injury or disease.

Stem cell research 2019

Assuming that adult stem cells from a specific source e. The stem cells become attached to the plate and grow in the nutrient broth i. Some authorities have suggested they could be used as a potential treatment for diabetes. This research encompasses treatment of various disorders including organ regeneration, cardiovascular improvements, diabetes, and neurodegenerative conditions. This work provides important data and support toward the use of platelet lysate as a viable alternative to fetal bovine serum in a scalable suspension cell culture setup. Ohio had previously proposed funding dedicated to adult stem cell research. This caveat makes the assumption that stem cell transplants are replacing the dying cells. Therefore, their use in treatments could be fraught with problems, at least until a clearer understanding emerges regarding the signals that turn them on and off in their growth cycles. Research involving adult stem cells is not limited under the current federal restrictions. These patents were revoked in April by the U.

In the end, the data were found to be fraudulent, and some of the female researchers had apparently been coerced to donate their own eggs for the process of obtaining stem cells, a significant ethical breach in the field.

The fourth main controversy concerns whether adult stem cells are as beneficial as embryonic stem cells. They can either be frozen for storage or continue replicating. Also, due to their presence in adults, it is likely that the cells could have accumulated abnormalities through continuous exposure of the organism to environmental hazards such as viruses or to replication errors.

stem cell research articles 2018

This procedure has yet to be tested to determine if the valve is functional in vivo, but it clearly represents a promising discovery.

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