An analysis of the clinical factors of dementia a cognitive impairment
It must be borne in mind that depression and anxiety assessments in the NPI are single-item responses, in comparison with other screening tools assessing 15 to 30 items. Similarly, in a population of 60 Italian older adults followed for a mean of 4 years, any type of MCI increased the risk for any dementia HR 3.
Our cohort consisted of patients with MCI Experimental models could help us to further unravel the aetiology and identify treatment targets.
How fast does mild cognitive impairment progress
While awaiting these further research developments, cognitive dysfunction in diabetes does already affect daily clinical care. No date ranges for publications were specified. Patients in the latter group are the most relevant for patient management and are the focus of this Review. This construct captures a stage between normal cognition and dementia that identifies individuals who are at high risk of transition to dementia. Thus 20 papers are included in the final analysis Fig 1. Experimental models could help us to further unravel the aetiology and identify treatment targets. Palmer et al reported that a diagnosis of apathy in amnestic-MCI patients represented a 7-fold increased risk of developing AD [ 23 ]. The cost of any risk tool will determine recommendations about the use of the risk tool in clinical practice [ 12 ].
Apathy lack of motivation and decreased emotional engagement is a prevalent behavioral manifestation in MCI patients. Dementia is a public health problem with increase prevalence and relationship with aging population.
Mild cognitive impairment test
It has been investigated about clinical factors that are associated with cognitive deterioration in MCI. A number of risk prediction tools have been developed to stratify patients by risk of dementia [ 12 , 13 ], drawing on demographic, health, lifestyle, functioning and cognitive factors, as well as blood based biomarkers, genetics and brain imaging. This team used 14 clinical variables, but many more conditions and medications have been associated with dementia. Of these 64 abstracts were examined, and 8 papers in full text. Many health conditions are more prevalent in the older population. As a consequence, there is an increased co-occurrence of diabetes mellitus and dementia. Risk factors were measured before dementia diagnosis. The combination of consistent antidepressant treatment flexible regimen with or without donepezil in older adults with major depression was recently evaluated.
The development of targeted treatment and preventive strategies will therefore depend on these translational efforts. J Neurol Neurosci. This diagnostic approach, however, is clearly not specific or sensitive enough to determine the actual aetiology Animal models that adequately capture the heterogeneity of diabetes seen in humans are essential to uncover a pathological substrate for cognitive dysfunction and dementia in T2DM.
Only two-thirds of dementia cases are currently recorded in primary care, so increasing the proportion of cases diagnosed is a strategic priority for the UK and internationally. The amnestic type, characterized by memory impairment, is the most common, but other subtypes such as single non-memory and multiple domain, also are prevalent.
Of note, however, we must not regard cognitive dysfunction in relation to diabetes as a unitary construct. The American Academy of Neurology defined MCI as those patients with memory problems preferably corroborated by an informant, but with a normal global cognitive functioning and intact activities of daily living [ 7 ].
The cost of any risk tool will determine recommendations about the use of the risk tool in clinical practice [ 12 ].
based on 75 review